Though this discovery is limited to animal models, Dr Ng said there are genetic similarities to human samples, and human trials are ongoing. "Our study suggests that there may be new ways to treat the disease rather than just the symptoms, leading to better health outcomes and quality of life for people who suffer from osteoarthritis." "Known comorbidities of osteoarthritis include heart, pulmonary, and kidney disease, mental and behavioural conditions, diabetes, and cancer," said Dr Ng. While Dr Ng describes current treatments for osteoarthritis as a "Band-Aid approach," this new understanding could lead to a pharmaceutical treatment that reverses osteoarthritis and helps to address health outcomes associated with the disease. "With this new information, we are now able to explore pharmaceutical options to directly target the stem cell population that is responsible for the development of articular cartilage and progression of osteoarthritis." Gremlins - Evil Gremlin Puppet Prop MSRP: 9. "The findings of our study reimagine osteoarthritis not as a 'wear and tear' condition but as an active, and pharmaceutically reversible loss of critical articular cartilage stem cells," said the University of Adelaide's Dr Jia Ng from the Adelaide Medical School, who co-led the study. noise and overall performance when the product is used as a lubricant or fuel. It challenges the categorisation of osteoarthritis as wear and tear. Gremlin 1 cells present opportunities for cartilage regeneration and their discovery will have relevance to other forms of cartilage injury and disease, which are notoriously challenging to repair and treat. Treatment with fibroblast growth factor 18 (FGF18) stimulated the proliferation of Gremlin 1 cells in joint cartilage in mice, leading to significant recovery of cartilage thickness and reduced osteoarthritis. University of Adelaide researchers discovered a novel population of stem cells - marked by the Gremlin 1 gene - responsible for the progression of osteoarthritis. Often described as a 'wear and tear' condition, factors such as ageing, obesity, injury and family history contribute to the progression of osteoarthritis. Its treatment cost the Australian health system an estimated $3.9 billion in 2019-20. It is a long-term and progressive condition which affects people's mobility and has historically had no cure. Osteoarthritis is the degeneration of cartilage and other tissues in joints and is the most common form of arthritis in Australia, with one in five people over the age of 45 having the condition.
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